Total synthesis of (+)-18-epi-latrunculol A.
نویسندگان
چکیده
An enantioselective total synthesis of the cytotoxic latrunculin congener (+)-18-epi-latrunculol A has been achieved. Key steps in the synthetic route include an acid-mediated enone cyclization/equilibration sequence, a Carreira alkynylation, and a late-stage Mitsunobu macrolactonization to construct the macrolide skeleton.
منابع مشابه
Total Synthesis of (+)-18-epi-Latrunculol A: Development of a Synthetic Route
The evolution of an enantioselective total synthesis of (+)-18-epi-latrunculol A, a congener of the marine-sponge-derived latrunculins A and B, is reported. Key steps include a late-stage Mitsunobu macrolactonization to construct the 16-membered macrolactone, a mild Carreira alkynylation to unite the northern and southern hemispheres, a diastereoselective, acid-mediated δ-hydroxy enone cyclizat...
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عنوان ژورنال:
- Organic letters
دوره 15 17 شماره
صفحات -
تاریخ انتشار 2013